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Sichuan
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2020-08-02 00:06
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Sichuan
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Product description
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Product name: Alpha Cyperone Synonym name: (+)-Alpha Cyperone; 4,11-Selinadien-3-one; (-)-Alpha Cyperone, 23665-61-4 Catalogue No.: BP0152 Cas No.: 473-08-5 Formula: C15H22O Mol Weight: 218.3 |
Botanical Source: Cyperus rotundus L. Type of Compound: Sesquiterpenoids Purity: 95%~99% Analysis Method: HPLC-DAD or/and HPLC-ELSD Identification Method: Mass, NMR Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. Packing: Brown vial or HDPE plastic bottle |
Storage:Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams
Inquire for bulk scale.
Biological Activity
Alpha-cyperone is associated with the down-regulation of COX-2,IL-6,Nck-2,Cdc42 and Rac1, resulting in reduction of inflammation. which would be highly beneficial for treatment of inflammatory diseases such as AD. Alpha-cyperone is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium, it also shows inhibitory effects on adherence and invasion of avian pathogenic Escherichia coli O78 to chicken type II pneumocytes.
References
Vet Immunol Immunopathol. 2014 May 15;159(1-2):50-7.
Inhibitory effects of α-cyperone on adherence and invasion of avian pathogenic Escherichia coli O78 to chicken type II pneumocytes.
METHODS AND RESULTS:
Avian pathogenic Escherichia coli (APEC) are extra-intestinal pathogenic E. coli, and usually cause avian septicemia through breaching the blood-gas barrier. Type II pneumocytes play an important role of maintaining the function of the blood-gas barrier. However, the mechanism of APEC injuring type II pneumocytes remains unclear. α-cyperone can inhibit lung cell injury induced by Staphylococcus aureus. In order to explore whether α-cyperone regulates the adherence and invasion of APEC-O78 to chicken type II pneumocytes, we successfully cultured chicken type II pneumocytes.
CONCLUSIONS:
The results showed that α-cyperone significantly decreased the adherence of APEC-O78 to chicken type II pneumocytes. In addition, α-cyperone inhibited actin cytoskeleton polymerization induced by APEC-O78 through down regulating the expression of Nck-2, Cdc42 and Rac1. These results provide new evidence for the prevention of colibacillosis in chicken.
J Microbiol Biotechnol. 2012 Aug;22(8):1170-6.
α-cyperone alleviates lung cell injury caused by Staphylococcus aureus via attenuation of α-hemolysin expression.
METHODS AND RESULTS:
In this study, we aimed to evaluate the effect of α- cyperone on S. aureus. We used a hemolysin test to examine the hemolytic activity in supernatants of S. aureus cultured with increasing concentrations of α- cyperone. In addition, we evaluated the production of α- hemolysin (Hla) by Western blotting. Real-time RT-PCR was performed to test the expression of hla (the gene encoding Hla) and agr (accessory gene regulator). Furthermore, we investigated the protective effect of α- cyperone on Hla-induced injury of A549 lung cells by live/ dead and cytotoxicity assays. We showed that in the presence of subinhibitory concentrations of α-cyperone, Hla production was markedly inhibited. Moreover, α- cyperone protected lung cells from Hla-induced injury.
CONCLUSIONS:
These findings indicate that α-cyperone is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium. Thus, α-cyperone may provide the basis for a new strategy to combat S. aureus pneumonia.
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